Urea based foldamers

N,N?-linked oligoureas are a class of enantiopure, sequence-defined peptidomimetic oligomers without amino acids that form well-defined and predictable helical structures akin to the peptide ?-helix. Oligourea-based foldamers combine number features—such as synthetic accessibility, sequence modularity, folding fidelity—that bode well for their use in range applications from medicinal chemistry catalysis. Moreover, it was recently recognized this backbone can be combined with regular peptides generate helically folded peptide-oligourea hybrids display additional features terms helix mimicry protein-surface recognition properties. Here we provide detailed protocols preparation requested monomers synthesis purification homo-oligoureas hybrids.